Table 1.

Endogenous factors that modulate endothelial cell growth

Proangiogenic FactorsAntiangiogenic Factors
Vascular endothelial growth factor (VEGF)Angiostatin
Basic fibroblast growth factor (bFGF, FGF2)Endostatin
Transforming growth factor–β (TGF-β)Thrombospondin-1
Transforming growth factor–α (TGF-α)SPARC
Hepatocyte growth factor (HGF)Vascular endothelial growth inhibitor (VEGI)
Prostaglandin E2 (PGE2)METH-1, METH-2
Platelet-derived endothelial cell growth factor (PD-ECGF)
Angiogenin
Interleukin–8 (IL-8)
Angiopoietin