Table 4.

Mortality rates for and relative hazards of death resulting from cardiovascular disease and all causes, according to serum creatinine level

OverallGFRaP Trend
≥90 ml/min70 to 89 ml/min<70 ml/min
a Cutoffs correspond to the 5th and 20th percentiles of the estimated GFR distribution for the United States population.
b Reference category.
c Adjusted for age, race, gender, systolic BP, total cholesterol level, body mass index, diabetes mellitus, history of myocardial infarction or stroke, current cigarette smoking, physical inactivity, and education level.
Person years at risk84,02565,10114,1344791
All causes
    no. of patients1240  797269174
    no. of deaths/1000 person-yr 9.7  8.313.727.5
    age-, race-, and gender-adjusted relative hazard  1.0b0.91 (0.79 to 1.06)1.51 (1.21 to 1.87)0.055
    multivariate adjusted relative hazardc  1.0b0.96 (0.81 to 1.15)1.51 (1.19 to 1.91)0.001
Cardiovascular disease
    no. of patients 797  481182134
    no. of deaths/1000 person-yr 5.8  4.68.620.5
    age-, race-, and gender-adjusted relative hazard  1.0b0.91 (0.75 to 1.11)1.75 (1.39 to 2.20)0.003
    multivariate adjusted relative hazardc  1.0b0.96 (0.79 to 1.17)1.68 (1.33 to 2.13)0.001
Coronary disease
    no. of patients 390  2229177
    no. of deaths/1000 person-yr 2.7  2.04.411.4
    age-, race-, and gender-adjusted relative hazard  1.0b1.00 (0.73 to 1.37)1.86 (1.39 to 2.49)<0.001
    multivariate adjusted relative hazardc  1.0b1.01 (0.74 to 1.38)1.68 (1.23 to 2.30)<0.001
Congestive heart failure
    no. of patients 160  964024
    no. of deaths/1000 person-yr 1.1  0.92.03.3
    age-, race-, and gender-adjusted relative hazard  1.0b0.97 (0.59 to 1.58)1.19 (0.60 to 2.35)0.69
    multivariate adjusted relative hazardc  1.0b0.98 (0.59 to 1.60)1.12 (0.57 to 2.17)0.82