Table 2.

Comparison of the pharmacokinetic (PK) parameters for MPA and free MPA at the four PK sampling periods posttransplant in 54 pediatric renal transplant recipientsa

Parameter1 wk3 wk3 mo6 mo
MPAFree MPAMPAFree MPAMPAFree MPAMPAFree MPA
a Data are median (range). Values sharing common superscripts are not significantly different, whereas values without common superscripts are significantly different (P < 0.05).
C0 (mg/L)1.06a0.01c0.97a0.01c2.25b0.02c2.92b0.02c
(0.11 to 4.13)(<0.01 to 0.09)(0.06 to 15.6)(<0.01 to 0.15)(0.35 to 11.2)(<0.01 to 0.17)(0.18 to 12.6)(<0.01 to 0.11)
C12 (mg/L)0.92a0.01c0.92a0.01c1.65a0.01c2.31b0.02c
(0.11 to 6.96)(<0.01 to 0.11)(0.00 to 13.2)(<0.01 to 0.10)(0.28 to 6.89)(<0.01 to 0.10)(0.25 to 12.2)(<0.01 to 0.22)
Cmax (mg/L)9.95a0.17c15.3a0.20c24.9b0.23c26.0b0.21c
(1.50 to 42.3)(0.03 to 0.61)(3.53 to 45.7)(0.03 to 0.65)(7.20 to 53.5)(0.08 to 0.61)(9.40 to 52.5)(0.07 to 0.57)
AUC0–12 (mg × h/L)36.0a0.41c33.6a0.41c63.5b0.49c65.7b0.51c
(3.12 to 95.0)(0.07 to 1.58)(12.8 to 89.1)(0.13 to 1.19)(28.6 to 139)(0.17 to 1.40)(21.3 to 117)(0.18 to 1.34)