Table 4.

Correlation of the MPA PK parameters, C0, C12, and Cmax, and the abbreviated profiles, MPA-AUC0,75min,4h and MPA-AUC0–2, with the full-time MPA-AUC0–12 at the four PK sampling periods posttransplant in 54 pediatric renal transplant recipients

PK Parameter1 wk3 wk3 mo6 moEntire Study Period
MPA C0r = 0.65r = 0.70r = 0.59r = 0.50r = 0.64
P < 0.0001P < 0.0001P < 0.0001P < 0.01P < 0.0001
MPA C12r = 0.69r = 0.56r = 0.49r = 0.47r = 0.52
P < 0.0001P < 0.0001P < 0.01P < 0.01P < 0.0001
MPA-Cmaxr = 0.53r = 0.52r = 0.68r = 0.64r = 0.71
P < 0.005P < 0.005P < 0.0001P < 0.0001P < 0.0001
MPA-AUC0,75min,4hr = 0.89r = 0.86r = 0.80r = 0.85r = 0.90
P < 0.0001P < 0.0001P < 0.0001P < 0.0001P < 0.0001
MPA-AUC0–2r = 0.82r = 0.86r = 0.77r = 0.77r = 0.85
P < 0.0001P < 0.0001P < 0.0001P < 0.0001P < 0.0001