Table 5.

Areas under the receiver operating characteristic (ROC) curves for pharmacokinetic parameters of total and free MPA to discriminate between patients with (n = 12) or without an acute rejection episode during the first 70 d posttransplant

PK ParameterArea Under the ROC Curve95% Confidence IntervalP
MPA C0 (mg/L)0.630.46 to 0.790.07
MPA C12 (mg/L)0.740.60 to 0.880.0006
MPA Cmax (mg/L)0.610.44 to 0.790.10
MPA-AUC0–12 (mg × h/L)0.700.55 to 0.860.005
MPA-AUC0,75min,4h (mg × h/L)0.700.53 to 0.870.009
MPA-AUC0–2 (mg × h/L)0.650.49 to 0.810.03
Free MPA C0 (mg/L)0.530.36 to 0.710.36
Free MPA C12 (mg/L)0.630.43 to 0.840.10
Free MPA Cmax (mg/L)0.510.30 to 0.710.47
Free MPA-AUC0–12 (mg × h/L)0.520.33 to 0.720.40