Table 7.

Areas under the ROC curves for pharmacokinetic parameters of total and free MPA to discriminate between patients with or without adverse events of infections (n = 9) and/or leukopenia (n = 3) in the stable phase posttransplant

PK ParameterArea Under the ROC Curve95% Confidence IntervalP
MPA C0 (mg/L)0.510.32 to 0.700.46
MPA C12 (mg/L)0.530.33 to 0.730.38
MPA Cmax (mg/L)0.590.40 to 0.780.18
MPA-AUC0–12 (mg × h/L)0.560.37 to 0.760.26
MPA-AUC0,75min,4h (mg × h/L)0.630.44 to 0.820.09
MPA-AUC0–2 (mg × h/L)0.520.34 to 0.710.41
Free MPA C0 (mg/L)0.560.36 to 0.760.28
Free MPA C12 (mg/L)0.550.34 to 0.760.32
Free MPA Cmax (mg/L)0.710.55 to 0.870.006
Free MPA-AUC0–12 (mg × h/L)0.710.54 to 0.880.007