Table 1.

Baseline biochemical data for patients provided single orally administered doses of AMG 073 or placeboa

Dose (mg)Plasma PTH (pg/ml)Serum Calcium (mg/dl)Serum Phosphorus (mg/dl)
a Values are expressed as mean ± SD. PTH, parathyroid hormone.
Placebo (n = 12)599 ± 3629.9 ± 0.56.5 ± 1.8
5 (n = 8)566 ± 28110.4 ± 0.86.9 ± 1.8
10 (n = 8)473 ± 28410.2 ± 0.75.7 ± 1.3
25 (n = 6)752 ± 5809.7 ± 1.05.1 ± 1.3
50 (n = 6)490 ± 3409.7 ± 1.96.5 ± 1.6
75 (n = 6)696 ± 48210.1 ± 0.95.8 ± 1.7
100 (n = 6)919 ± 4799.5 ± 0.96.0 ± 1.6