Table 2.

Baseline biochemical results for patients provided daily orally administered doses of 10, 25, 50, or 50/25a mg of AMG 073 or placebo for 8 d

Dose (mg)Plasma PTH (pg/ml)Serum Calcium (mg/dl)Serum Phosphorus (mg/dl)
a Doses were reduced from 50 to 25 mg during the first several days of treatment. Values are expressed as mean ± SD. PTH, parathyroid hormone.
Placebo (n = 7)767 ± 4579.7 ± 0.55.9 ± 1.9
10 (n = 8)553 ± 37010.2 ± 1.27.0 ± 1.8
25 (n = 6)527 ± 2399.6 ± 0.56.7 ± 2.1
50 (n = 6)824 ± 6949.5 ± 0.75.0 ± 1.1
50/25 (n = 3)578 ± 2349.9 ± 1.06.8 ± 0.9