Table 2.

Risk factors for de novo CHF as determined by Cox regression in 638 adult patients who were alive with functioning graft and free of clinical heart disease (CAD or CHF) at 1 yra

VariableUnivariateMultivariate
Relative Risk (95% CI)PRelative Risk (95% CI)P
a CHF, congestive heart failure; CAD, coronary artery disease.
b Past or current smoker.
c Gault-Cockroft estimate.
Age (decade)1.63 (1.34 to 1.99)<0.0011.43 (1.16 to 1.77)0.001
Female gender1.49 (0.91 to 2.45)0.1
Diabetes3.14 (2.01 to 4.90)<0.0012.30 (1.43 to 3.69)0.001
Smokerb1.59 (0.94 to 2.67)0.08
Creatinine clearance (per 10 ml/min)c0.72 (0.61 to 0.86)<0.001
Hemoglobin (per 10 g/L decrease)1.20 (1.06 to 1.36)0.0041.24 (1.10 to 1.39)0.001
Serum total cholesterol (per 10 mmol/L)1.06 (0.88 to 1.28)0.6
Serum albumin (per 10 g/L decrease)2.77 (1.56 to 4.90)<0.0012.10 (1.08 to 4.07)0.03
Systolic BP (per 10 mmHg)1.47 (1.28 to 1.66)<0.0011.29 (1.10 to 1.50)0.001
Diastolic BP (per 10 mmHg)1.80 (1.35 to 1.41)<0.001
Transplanted > 19851.37 (0.80 to 2.34)0.2
Acute allograft rejection1.97 (1.07 to 3.63)0.03
Delayed graft function1.36 (0.80 to 2.32)0.2
Cadaveric donor5.18 (2.07 to 12.9)<0.0013.18 (1.24 to 8.18)0.02
Cyclosporine use1.42 (0.81 to 2.48)0.2
Duration of dialysis (per mo)0.95 (0.84 to 1.08)0.4
Center0.6 (0.32 to 1.19)0.2