Table 3.

Risk factors for de novo IHD as determined by Cox regression in 638 adult patients who were alive with functioning graft and free of clinical heart disease at 1 yra

VariableUnivariateMultivariate
Relative Risk (95% CI)PRelative Risk (95% CI)P
a IHD, ischemic heart disease.
b Past of current smoker.
c Gault-Cockroft estimate.
Age (per decade)1.50 (1.23 to 1.84)<0.0011.45 (1.18 to 1.78)<0.001
Female gender0.28 (0.14 to 0.58)<0.0010.32 (0.16 to 0.65)0.002
Diabetes3.11 (2.01 to 4.82)<0.0012.40 (1.49 to 3.87)<0.001
Smokerb0.99 (0.60 to 1.64)1.0
Creatinine clearance (per 10 ml/min)c0.93 (0.79 to 1.08)0.3
Hemoglobin (per 10 g/L)1.03 (0.88 to 1.18)0.7
Serum total cholesterol (per mmol/L)1.05 (0.87 to 1.28)0.6
Serum albumin (per 10 g/L)1.52 (0.80 to 2.89)0.2
Systolic BP (per 10 mmHg)1.25 (1.08 to 1.44)0.002
Diastolic BP (per 10 mmHg)1.72 (1.28 to 2.30)<0.0011.41 (1.03 to 1.94)0.03
Transplanted > 19851.00 (0.58 to 1.74)1.0
Acute allograft rejection3.01 (1.48 to 6.11)0.0022.68 (1.32 to 5.47)0.007
Delayed graft function1.01 (0.51 to 2.00)1.0
Cadaveric donor2.19 (0.93 to 5.12)0.07
Cyclosporine use1.11 (0.63 to 1.96)0.7
Duration of dialysis1.01 (0.92 to 1.13)0.7
Center0.43 (0.21 to 0.92)0.03