Table 5.

Clinical and hormonal characteristics of hypertensive patients, according to the R53H polymorphisma

Population 1, Ad Libitum DietPopulation 2
High-Na+ DietLow-Na+ Diet
RR (n = 68)RH (n = 6)RR (n = 151)RH (n = 13)RR (n = 151)RH (n = 13)
a The low-Na+ diet had a significant effect (P < 0.05) on the active renin concentration, plasma renin activity (PRA), plasma and urinary aldosterone concentrations, and urinary kallikrein activity (not shown). BMI, body mass index; SBP, systolic BP; DBP, diastolic BP; LBK, lysine-bradykinin; Ang I, angiotensin I; TU, TAME unit, (millimole p-tosyl-L-arginine methyl ester hydrolyzed/mn; FU, fluorescence unit; Nmec, 7 amino 4 methyl coumarin; RR, R53 homozygotes; RH, R534 homozygotes.
b P = 0.08.
c P < 0.05, RH compared with RR.
d n = 61.
e n = 5.
Age (yr)47.3 ± 8.844.8 ± 9.548.4 ± 7.446.8 ± 7.4
Gender (M/F)46/225/182/696/7
BMI (kg/m2)25.0 ± 2.525.3 ± 2.426.6 ± 13.128.0 ± 5.0
SBP (mmHg)163.7 ± 13.1165.3 ± 13.7150.5 ± 19.3155.0 ± 19.5137.3 ± 29.0135.4 ± 14.2
DBP (mmHg)105.6 ± 6.8103.7 ± 6.488.9 ± 12.390.2 ± 10.081.6 ± 11.980.9 ± 7.4
Plasma
    active renin (pg/ml)14.8 ± 12.010.5 ± 5.936.1 ± 29.027.6 ± 14.0
    PRA (ng/Ang I per ml)0.8 ± 0.70.6 ± 0.50.69 ± 0.590.53 ± 0.592.3 ± 2.11.9 ± 1.7
    aldosterone (μg/24 h)116 ± 54154 ± 10268.0 ± 46.256.7 ± 4.7182 ± 107199 ± 15
Urine
    Na+ (mmol/24 h)118 ± 60132 ± 45205 ± 70199 ± 6715.0 ± 916.0 ± 8
    K+ (mmol/24 h)65 ± 3568 ± 4267 ± 2066 ± 2671 ± 1966 ± 18
    aldosterone (μg/24 h)8.3 ± 4.99.4 ± 3.413.7 ± 8.215.6 ± 7.730.9 ± 21.136.0 ± 19
Urinary kallikrein
    kinin-forming assay (pg LBK/min per 24 h)106 ± 8258 ± 59b
    esterase assay (TU/24 h)0.519 ± 0.3940.400 ± 0.2821.021 ± 0.8130.511 ± 0.464c
    d-PFF-NMec assay (ΔFU/24 h)15.9 ± 2.05d1.53 ± 0.82ce36.3 ± 3.71d9.12 ± 2.36ce