Table 1.

Whole animal dataa

Sham (n = 3)5/6-NPX (n = 7)5/6-NPX + IS (n = 7)
0 wk16 wk0 wk4 wk10 wk16 wk0 wk4 wk10 wk16 wk
a All results are mean ± SEM.
b P < 0.05;
c P < 0.01;
d P < 0.001 by Fisher’s PSLD test (ANOVA) as compared with normal rats at the same week.
e P < 0.05;
f P < 0.01;
g P < 0.001 as compared with 5/6-nephrectomized (5/6-NPX rats) at the same week.
Body wt (g)480 ± 20600 ± 34448 ± 9494 ± 10522 ± 15527 ± 14b439 ± 10477 ± 13505 ± 13511 ± 14c
Food intake (g/d)25.4 ± 1.024.2 ± 2.224.5 ± 0.424.6 ± 0.424.3 ± 1.023.6 ± 1.023.8 ± 0.423.4 ± 0.624.3 ± 0.822.0 ± 1.4
Systolic BP (mmHg)137 ± 4130 ± 9216 ± 11d219 ± 8209 ± 7216 ± 7d198 ± 9d210 ± 8197 ± 12213 ± 13d
Serum creatinine (mg/dl)0.4 ± 0.10.4 ± 0.11.3 ± 0.1d1.4 ± 0.11.6 ± 0.11.8 ± 0.1d1.3 ± 0.1d1.6 ± 0.22.1 ± 0.2e2.3 ± 0.1d,f
BUN (mg/dl)23 ± 120 ± 177 ± 2d88 ± 589 ± 5101 ± 5d82 ± 3d90 ± 6103 ± 4f115 ± 3d,f
Creatinine clearance (ml/min)2.59 ± 0.073.39 ± 0.230.90 ± 0.05d0.93 ± 0.070.84 ± 0.090.76 ± 0.07d0.88 ± 0.07d0.74 ± 0.10.63 ± 0.090.45 ± 0.04d,f
Serum IS (μM)7.50 ± 1.4112.7 ± 0.4734.6 ± 7.50b39.4 ± 4.6943.6 ± 6.1055.3 ± 7.50b47.8 ± 10.3d157 ± 13.1g195 ± 28.6g227 ± 22.5d,g
Urinary IS excretion (mg/d)2.93 ± 0.113.01 ± 0.493.88 ± 0.283.97 ± 0.513.90 ± 0.523.90 ± 0.443.88 ± 0.2824.3 ± 1.37g31.1 ± 2.0g29.2 ± 1.6d,g
Urinary protein excretion (mg/d)13.2 ± 4.913.3 ± 4.481.5 ± 11.3d84.9 ± 10.291.5 ± 14.3104 ± 12d82.1 ± 11.0d97.4 ± 19.5154 ± 27e168 ± 34d,e