Table 4.

Clinical and histologic features of common deletion-positive or -negative patients

ClassificationAge (Range) (yr)Serum Creatinine Concentration (mg/dl)Proteinuria (g/d)Global Sclerosis (%)aSegmental Sclerosis (%)aSegmental Lesions (%)a,b
a Number of affected glomeruli/number of total glomeruli in the section.
b Number of glomeruli containing segmental sclerotic lesions and/or adhesions.
c P < 0.05, compared with common deletion-negative patients.
Primary FGS
    common deletion-positive26.5 (14 to 75)1.1 (0.7 to 8.5)4.9 (0.6 to 21.8)5.6 (0 to 23.1)12.7 (3.8 to 50.0)25.4 (3.8 to 100.0)
    common deletion-negative36.5 (19 to 84)1.2 (0.6 to 2.4)2.3 (1.0 to 7.0)3.1 (0.0 to 35.7)29.9 (4.0 to 75.0)35.5 (4.0 to 75.0)
Familial FGS
    common deletion-positive24 (23 to 58)1.2 (0.7 to 2.4)2.4 (1.3 to 6.3)28.6 (11.1 to 73.7)14.3 (5.3 to 44.4)14.3 (5.3 to 88.9)
    common deletion-negative32 (11 to 45)0.9 (0.4 to 1.4)2.2 (1.0 to 3.0)36.4 (0.0 to 60.0)25.0 (22.7 to 40.0)25.0 (22.7 to 40.0)
IgA nephropathy
    common deletion-positive50.5 (19 to 73)0.9 (0.6 to 1.1)2.3 (0.3 to 4.0)13.2 (11.5)1.6 (0.0 to 23.0)27.9 (17.0 to 100.0)c
    common deletion-negative35.5 (13 to 71)0.9 (0.5 to 1.7)1.4 (0.8 to 4.0)2.2 (0.0 to 21.1)0.0 (0.0 to 13.0)17.7 (0.0 to 30.4)