Table 1.

Series A: Systemic and whole kidney data in control and diabetic Sprague-Dawley rats on low- versus high-NaCl dieta

Control RatsDiabetic Rats
Low-NaCl (n = 6)High-NaCl (n = 8)Low-NaCl (n = 6)High-NaCl (n = 8)
a Data are mean ± SE. UV, UNaV, or UCIV, urinary excretion of fluid, Na, or CI, respectively; BGL, blood glucose level; Hct, hematocrit. ND, not determined.
b P < 0.05 vs. high-NaCl.
Metabolic cage experiments
    UV (ml/d)21 ± 531 ± 2132 ± 5089 ± 20
    UNaV (mmol/d)0.1 ± 0.1b8.2 ± 0.90.6 ± 0.1b6.2 ± 0.7
    UCIV (mmol/d)0.1 ± 0.1b8.8 ± 1.00.4 ± 0.2b6.9 ± 0.7
Micropuncture experiments
    Body wt (g)424 ± 19434 ± 18327 ± 7340 ± 7
    BGL (mg/dl)NDND442 ± 30438 ± 31
    Hct (%)51 ± 150 ± 150 ± 150 ± 1
    UV (μl/min)2.7 ± 0.36.0 ± 1.617 ± 511 ± 5
    UNaV (μmol/min)0.06 ± 0.01b0.34 ± 0.140.09 ± 0.02b0.49 ± 0.09
    UCIV (μmol/min)0.07 ± 0.01b1.12 ± 0.230.21 ± 0.07b0.95 ± 0.09