Table 2.

Effects of OVX and 17β-E2 supplementation in ratsa

Sham(n = 5)OVX(n = 5)OVX + E2L(n = 5)OVX +E2M(n = 5)OVX +E2H(n = 5)
a OVX, ovariectomized;17β-E2, 17β-estradiol; +E2L, supplemented with 2 × 32 μg 17β-E2/d; +E2M, supplemented with 2 × 125 μg 17β-E2/d;+E2H, supplemented with 2 × 500 μg 17β-E2/d. Data are presented as mean ± SEM.
bP < 0.05versus sham.
cP < 0.05versus OVX.
dP < 0.05versus all groups.
eP < 0.05versus OVX, OVX plus low-dose 17β-E2, and OVX plus medium-dose 17β-E2.
fP < 0.0001versus all groups.
Body weight (g)
    beginning207 ± 4205 ± 4207 ± 3209 ± 4204 ± 2
    final203 ± 4215 ± 3b207 ± 4202 ± 4c189 ± 4d
Uterus weight (g)0.51 ± 0.070.23 ± 0.04b0.21 ± 0.010.39 ± 0.040.66 ± 0.13e
Serum level
    17β-E2 (pg/ml)11 ± 65 ± 35 ± 112 ± 264 ± 6f
    Ca2+ (mM)2.38 ± 0.022.40 ± 0.032.39 ± 0.022.36 ± 0.042.31 ± 0.02c