Table 1.

Summary of comparative analysis of VEGF synthesis and effects in RPTEC and GEC

RPTECGEC
VEGF, vascular endothelial growth factor; RPTEC, proximal tubular epithelial cells; GEC, glomerular epithelial cells; ++, marked increase; +, increase; ±, no change; −, decrease.
VEGF mRNA expressionVEGF120, VEGF164VEGF120, VEGF164
VEGF-B mRNA expressionNoVEGF B167, VEGF B186
VEGF-C mRNA expressionNoYes
VEGF-D mRNA expressionNoNo
Response to hypoxiaVEGF mRNA: ++VEGF mRNA: +
VEGF protein: +VEGF protein: +
Angiogenesis: +Angiogenesis: +
Response to high d-glucoseVEGF mRNA: +VEGF mRNA: ±
VEGF protein: +VEGF protein: +
Angiogenesis: −Angiogenesis: −
Response to high glucose and hypoxiaVEGF mRNA: ++VEGF mRNA: ±
VEGF protein: +VEGF protein: +
Angiogenesis: ±Angiogenesis: ±