Table 1.

Effects of interstitial infusion of enalaprilat, perindoprilat, and AngI on mean arterial pressure and plasma AngI and AngII concentrations in anesthetized ratsa

Mean ArterialPressure (mmHg)Plasma AngILevel (pM)Plasma AngIILevel (pM)AngII/AngI Ratio
a Values are means ± SEM. AngI, angiotensin I.
b P < 0.05 versus control.
Control (n = 5)116 ± 2119 ± 18115 ± 151.11 ± 0.12
Enalaprilat (1 mM in perfusate, 150 min)114 ± 3153 ± 13100 ± 230.67 ± 0.15b
Control (n = 8)115 ± 4202 ± 24172 ± 200.86 ± 0.06
Enalaprilat (10 mM in perfusate, 150 min)106 ± 4b1246 ± 251b122 ± 20b0.11 ± 0.02b
Control (n = 7)108 ± 595 ± 7106 ± 181.11 ± 0.15
Perindoprilat (10 mM in perfusate, 150 min)99 ± 5b690 ± 143b74 ± 11b0.12 ± 0.02b
Control (n = 7)110 ± 4147 ± 24138 ± 211.12 ± 0.25
AngI (100 nM in perfusate, 75 min)110 ± 4152 ± 19134 ± 150.99 ± 0.17
AngI plus enalaprilat (10 mM in perfusate, 75 min)100 ± 3b1603 ± 246b94 ± 12b0.06 ± 0.01b