Table 3.

Details of major bleeding eventsa

a All major bleeds occurred in patients allocated to warfarin.
• Patient 1: The patient was admitted to hospital with diarrhea and developed hematemesis while in the emergency department. Upper endoscopy revealed gastric erosions. The patient subsequently became hemodynamically unstable, and a decision to not use aggressive supportive measures was made. The INR at presentation was 1.6. The patient subsequently died.
• Patient 2: The patient underwent coronary angiography and became hypovolemic after the procedure. Surgical exploration, evacuation of a 2-L hematoma, and repair of a femoral artery injury was required to control bleeding. The INR at the time of the angiography was 1.4.
• Patient 3: The patient was involved in a motor vehicle accident and developed a left cerebral hematoma/contusion and right leg hematoma, which required surgical evacuation. An INR from the time of presentation was not available.
• Patient 4: This patient experienced two major bleeds. In the first case, the patient presented with epistaxis, which required hospitalization and cauterization. The INR at the time of presentation was 2.4. Subsequently, the patient was admitted with a decreased level of consciousness and melena. The INR was 1.3 at presentation. The patient was admitted, and over the next 3 d, the hemoglobin fell by 3 g/dl (30 g/L). The patient’s family did not desire investigation, and life support was discontinued.
• Patient 5: Patient was hospitalized for gastrointestinal bleeding. Upper gastrointestinal endoscopy showed distal esophageal ulcer and focal erosive gastritis. The hemoglobin fell with this event from 11.1 g/dl to 9.1 g/dl (111 g/L to 91 g/L). The INR at the time of presentation was 1.1.