Table 3.

Mutations tested in the X. laevis oocyte system

Subunit	Human Mutation	Tested in the X. laevis Oocyte as Expression System	% of the WT^a	Reference
^a WT, wild-type ENaC.
α	I68 frameshift	Human αI68fr ratβ ratγ	0.1%	138
	C133Y	Rat αC158Yβγ	71% at 19°C	139
			13% at 30°C
	R492 stop	Human αR492*βγ	2%	Bonny O, manuscript in preparation
	R508 stop	Human αR508*βγ	8%	42
		Rat αL535*βγ	13%
	S562L	Rat S589Lβγ	<0.1%	Gautschi I, Schild L, Kellenberger S, personal communication
β	G37S	Rat αβG37Sγ	50%	47, 106