Table 4. Comparison of CG and MDRD equations in previously published and current studiesa

Levey 1999Lewis 2001Bertolus 2001Bostom 2002Vervoot 2002Kingdon 2003Current Study
a BSA, body surface area; SCr, serum creatinine; NR, not reported.
Sample size16281703221099226100
SubjectsPatients with CKD in MDRD studyBlacks with CKD from hypertensionPotential renal donors with CrCl <80 ml/min by two 24-h urinesCKD cohort46 healthy adults/46 type 1 diabetics without nephropathyPatients with sclerodermaPotential kidney donors
Mean age (yr)5154404328/275841
% male60%69%27%77%46%23%42%
% black12%100%9%0%0%4%10%
Weight (kg)79.6 ± 16.890.271.4 ± 16.57669.9/71.5NR78.1 ± 15.7
(range 66–85)(range 44.1–113)
BSA (m2)1.91 ± 0.232.021.80 ± 0.21NR1.85/1.87NR1.9 ± 0.2
Mean SCr (mg/dl)2.31.851.11.20.9/0.8NR0.9
Measured GFR (ml/min per 1.73 m2)48.656.999.3109107/122NR112
(18–205)(70–169)
Type of GFR study125I-Iothalamate125I-Iothalamate99mTc-DTPAIohexolInulin51Cr-EDTA55 125I-Iothalamate/45 99mTc-DTPA
R or R2 for MDRD 1R2 = 0.90R = 0.90R2 = 0.005R2 = 0.31NRR = 0.79R2 = 0.15/0.40
(log transformed)(log transformed)
R or R2 for CG-GFRR2 = 0.80NRNRNRNRR = 0.71R2 = 0.05/0.21
(log transformed)
R or R2 for CGNRR = 0.85R2 = 0.14R2 = 0.17NRNRR2 = 0.04/0.18
(log transformed)
Absolute difference for MDRD 1 (ml/min per 1.73 m2)NR6.27NRNR9.0/11.8NR33.8/31.8
(median)(mean)(mean)
Absolute difference for CG (ml/min per 1.73 m2)NR8.34NRNR10.7/18.8NR33.8/31.7
(median)(mean)(mean)