Table 1. Crude and adjusted RR for diminished filtration according to EDN1 T-1370G and K198N polymorphisms based on single-SNP analysisa

CategoryDiminished Filtration
Crude RRAge and Gender RRConfounder RR
a RR indicates relative risk; EDN1, endothelin-1; and SNP, single nucleotide polymorphism.
EDN1 T-1370G(T/T)1.01.01.0
(T/G)1.1 (0.78 to 1.50)1.1 (0.77 to 1.48)0.9 (0.57 to 1.32)
(G/G)1.8 (0.88 to 3.51)1.8 (0.88 to 3.52)2.1 (0.92 to 4.57)
EDN1 K198N(K/K)1.01.01.0
(K/N)0.8 (0.60 to 1.15)0.8 (0.60 to 1.15)0.7 (0.49 to 1.09)
(N/N)1.6 (0.92 to 2.77)1.6 (0.90 to 2.70)1.5 (0.75 to 2.91)