Table 3. Population characteristics of the homozygous EDN1 1370G/198N haplotype carriers versus the remaining haplotype carriers in the PREVEND Studya

CategoryRemaining Haplotype CarriersHomozygous G-N Haplotype Carriers
a EDN1 indicates endothelin-1; PREVEND, Prevention of Renal and Vascular End-Stage Disease.
b P < 0.05.
n (%)7110 (97.5)181 (2.5)
Male gender (%)50.850.8
Age (yr)49 ± 1249 ± 13
Minimal waist circumference (cm)87.9 ± 1388.4 ± 13
Body mass index (kg/m2)25.9 ± 4.126.0 ± 4.1
Obesity (%)13.919.2b
Systolic BP (mmHg)128 ± 20129 ± 19
Diastolic BP (mmHg)74 ± 1075 ± 10
Hypertension (%)15.818.9
Glucose, mg/dl (mmol/L)84.68 ± 10.81 (4.7 ± 0.6)84.68 ± 12.61 (4.7 ± 0.7)
Cholesterol, mg/dl (mmol/L)216.22 ± 42.47 (5.6 ± 1.1)216.22 ± 38.61 (5.6 ± 1.0)
Hypercholesterolemia (%)24.626.4
Smoking (%)53.844.9
Urinary albumin excretion (mg/24 h)8.9 (6.2 to 15.7)8.5 (5.8 to 17.3)
Microalbuminuria (%)11.014.9
Serum creatinine, mg/dl (μmol/L)0.95 ± 0.19 (84 ± 17)0.95 ± 0.18 (84 ± 16)
Creatinine clearance, ml/min · 1.73 m292.9 ± 20.889.8 ± 21.1b
Diminished filtration (%)2.55.1b