Table 4. RR for diminished filtration and microalbuminuria according to carrier status of EDN1 haplotypes consisting of T-1370G and K198N polymorphisms in the PREVEND Studya

CategoryCrude RRAge and gender RRConfounder RR
a RR indicates relative risk; EDN1, endothelin-1; and PREVEND, Prevention of Renal and Vascular End-Stage Disease.
b P < 0.0001.
Diminished filtration
    remaining haplotype carriers1.01.01.0
    heterozygous G-N haplotype carriers1.0 (0.70 to 1.38)1.0 (0.69 to 1.37)0.8 (0.51 to 1.22)
    homozygous G-N haplotype carriers2.1 (1.04 to 4.18)b2.1 (1.04 to 4.17)b2.4 (1.07 to 5.33)
Microalbuminuria
    remaining haplotype carriers1.01.01.0
    heterozygous G-N haplotype carriers0.9 (0.77 to 1.09)0.9 (0.76 to 1.08)0.9 (0.74 to 1.19)
    homozygous G-N haplotype carriers1.3 (0.88 to 2.04)1.3 (0.84 to 2.04)0.9 (0.42 to 1.77)