Table 2. Patient characteristics associated with incident strokea

CovariateUnadjusted Hazard Ratio (95% CI) (N = 8920, 915 Strokes)Adjusted Hazard Ratio (95% CI) (N = 6862, 684 Strokes)P Value
a The multivariate model is adjusted for all variables listed in the table and is further adjusted for age, height, dialysis vintage, and DMMS study (wave 2, 3, or 4). Patients with missing covariate values were excluded from the multivariate model.
b There was significant interaction between race and prevalent cardiovascular disease (P = 0.001).
c Prevalent CVD is defined as a previous diagnosis of coronary artery disease, myocardial infarction, coronary artery bypass, angioplasty, cardiac arrest, or congestive heart failure.
d Mean BP = (systolic BP + 2*diastolic BP)/3. BP measurements were taken predialysis (for hemodialysis patients) or randomly (for peritoneal dialysis patients).
Raceb
    among patients without CVDc
        whiteReferentReferent
        black1.20 (0.96–1.50)1.24 (0.96–1.60)0.1
        Asian0.71 (0.29–1.74)0.56 (0.21–1.53)0.26
        other0.98 (0.60–1.61)0.76 (0.42–1.39)0.4
    among patients with CVDc
        whiteReferentReferent
        black0.70 (0.58–0.85)0.74 (0.60–0.92)0.007
        Asian0.77 (0.38–1.56)0.54 (0.24–1.23)0.15
        other0.66 (0.42–1.04)0.76 (0.48–1.23)0.3
Markers of malnutrition
    undernourished1.62 (1.33–1.97)1.27 (1.01–1.61)0.04
    serum albumin (per 1 g/dl decrease)1.72 (1.58–2.00)1.43 (1.17–1.74)<0.001
    weight (25% relative decrease)1.14 (1.07–1.21)1.09 (1.00–1.18)0.057
Mean BP (10 mmHg increase)d1.00 (0.95–1.05)1.11 (1.05–1.18)<0.001
Gender (female versus male)1.33 (1.17–1.52)0.96 (0.79–1.17)0.7
Age (per decade)1.42 (1.36–1.49)1.34 (1.26–1.42)<0.001
Renal disease
    primary GNReferentReferent
    hypertension1.41 (1.10–1.81)1.14 (0.87–1.50)0.3
    diabetes1.97 (1.55–2.50)1.36 (1.04–1.78)0.02
    PKD0.96 (0.67–1.39)1.03 (0.76–1.40)0.8
    other1.09 (0.83–1.44)0.72 (0.47–1.08)0.1
Renal replacement modality
    hemodialysisReferentReferent
    peritoneal dialysis1.04 (0.82–1.31)1.08 (0.79–1.47)0.6
    transplant0.21 (0.13–0.33)0.34 (0.20–0.57)<0.001