Table 7. Time-dependent analysisa of the impact of persistent or de novo LVH on the subsequent occurrence of CHF

Model VariablesRelative RiskP
a Extended Cox model in which LVH, BP, hemoglobin, serum albumin, and creatinine clearance are treated as time-dependent variables.
Model A
    LVH2.48 (1.18, 5.25)0.02
Model B
    age1.54 (1.18, 2.02)0.001
    DM3.59 (1.74, 7.40)0.001
    systolic BP (per 10 mmHg)1.21 (1.04, 1.41)0.01
    hemoglobin (per 10 g/L)1.62 (1.38, 1.88)<0.001
    albumin (per 10 g/L)3.23 (1.40, 7.83)0.01
Model C (BP and HGB excluded)
    LVH2.56 (1.20, 5.47)0.015
    age1.52 (1.16, 1.95)0.002
    diabetes2.90 (1.47, 5.72)0.001
    albumin (per 10 g/L decrease)2.46 (1.09, 5.51)0.03