Table 3. Effects on laboratory parameters of blockade of the renin angiotensin system in 18 type I diabetic patients with diabetic nephropathy

ParameterPlaceboBenazepril 20 mgValsartan 80 mgBenazepril 20 mg + Valsartan 80 mg
Values are mean (SEM) and a geometric mean (95% CI).
b P < 0.05 versus placebo;
c P < 0.01 dual blockade versus mono-therapy;
d P < 0.05 dual blockade versus mono-therapy;
e P < 0.05 dual blockade versus benazepril.
Renina (mU/L)30 (18 to 50)161 (72 to 364)b163 (82 to 325)b331 (133 to 823)bc
Angiotensin IIa (pmol/L)13 (9 to 17)7 (5 to 10)b44 (26 to 75)b11 (6 to 21)d
P-potassium (mmol/L)3.7 (0.1)4.0 (0.2)b3.9 (0.1)4.3 (0.1)bc
Hemoglobin (mmol/L)8.5 (0.3)8.2 (0.2)b8.1 (0.2)b7.8 (0.2)be
Hemoglobin A1c (%)9.1 (0.2)9.5 (0.2)9.2 (0.2)9.6 (0.2)b
P-cholesterol (mmol/L)5.5 (0.3)5.3 (0.3)4.9 (0.2)b4.8 (0.2)be
P-HDL (mmol/L)1.5 (0.1)1.5 (0.1)1.5 (0.1)1.4 (0.1)
P-LDL (mmol/L)3.4 (0.2)3.3 (0.2)2.9 (0.1)b2.7 (0.2)be
P-triglyceride (mmol/L)1.3 (0.2)1.2 (0.2)1.1 (0.1)1.3 (0.2)
U-sodium excretion (mmol/24 h)194 (17)204 (16)187 (13)195 (17)