Table 1. General features and clinical details of 179 children with sporadic nephrotic syndrome subdivided in two subgroups according to the response to steroidsa

nGender (F/M)Age at Proteinuria (mo)Follow-up from Onset of Proteinuria (mo)Cyclosporin Sensitivity n (Sens/Res/n.d.)Renal HistologyESRF nNPHS2 Mutations
HomHetR229Q
a 120 patients presented corticoresistance, 59 being treated with cyclosporin with variable response; 59 presented corticodependence and/or frequent relapses of proteinuria. MCN, minimal change nephropathy; Mes IgM, mesangial proliferation with IgM deposition; FSGS, focal segmental glomerulosclerosis; ESRF, end stage renal failure; Hom, homozygous; Het, heterozygous; n.d., not determined.
Nephrotic syndrome17975/10470 (1 to 216)108 (2 to 492)47/44/88MCN155914815
Mes IgM22
FSGS91
n.d.51
Corticodependence/frequent relapses5922/3740 (3 to 147)74 (2 to 233)25/2/32MCN41045
Mes IgM8
FSGS8
n.d.39
Corticoresistance12053/6771 (1 to 216)125 (1 to 492)22/42/56MCN115814410
Mes IgM14
FSGS83
n.d.12