Table 2. Effect of BMP-7 on proximal aortic calcification scores by groupa

Group1Group2Group3Group4Group5Group6
a The maximal total calcification score is six, the sum of the maximal intimal and medial scores. Three sections were analyzed from each animal for the presence (one) or absence (zero) of calcification yielding a maximal score of three for each compartment - media and intima. All values are mean ± SD, in arbitrary units (see text).
b Total score for group 4 is significantly higher than for group 1 (P < 0.01).
c Total score for group 6 is significantly lower than for group 1 (P < 0.01).
d Intimal score for group 4 is significantly higher than for group 1 (P < 0.01).
e In addition, the intimal score for group 6 is significantly lower than group 4 (P < 0.0002).
fMedial score for group 6 differs from group 1 (P < 0.01).
gGroup 4 and 6 differ from each other (P < 0.0003).
DietChowChowFatFatFatFat
SurgeryShamCRFShamCRFShamCRF
Rx--VehicleVehicleBMP-7BMP-7
n58791012
Total Score3.6 ± 1.63.8 ± 1.04.4 ± 2.15.7 ± 0.4b2.9 ± 2.90.5 ± 0.5c
Intimal Score1.0 ± 1.31.2 ± 0.92.0 ± 1.32.8 ± 0.4d1.5 ± 1.50.1 ± 0.2e
Medial Score2.6 ± 0.42.6 ± 0.42.4 ± 1.02.9 ± 0.2f1.4 ± 1.40.4 ± 0.5g