Table 3. Parameters of lipid metabolism

Cyclosporine (n = 60)Tacrolimus (n = 64)
Baseline3 Mo6 MoBaseline3 Mo6 Mo
Mean ± SD or median and interquartile range.
* P < 0.05;
P < 0.01;
P < 0.001 for comparison with baseline.
§ Conversion-factor: 1 U/L is approximately 0.7 mg/l (phenotype dependent).
Determined in two participating centers (41 cyclosporine patients and 42 tacrolimus patients).
Total cholesterol (mmol/L)5.86 ± 0.835.79 ± 0.705.80 ± 0.885.79 ± 0.855.26 ± 1.075.31 ± 0.89
LDL cholesterol (mmol/L)3.63 ± 0.743.49 ± 0.683.54 ± 0.813.48 ± 0.803.09 ± 0.753.11 ± 0.74
HDL cholesterol (mmol/L)1.43 ± 0.451.42 ± 0.501.40 ± 0.521.42 ± 0.431.41 ± 0.401.42 ± 0.41
Triglycerides (mmol/L)1.88 ± 0.912.04 ± 1.122.01 ± 0.942.11 ± 1.121.77 ± 1.101.72 ± 0.94
Apolipoprotein B (mg/L)1068 ± 1991056 ± 1901069 ± 2231018 ± 189938 ± 160935 ± 174
Lp(a) (U/L§144.5187.5193.0216.5223.5258.0
(51.3–478.3)(65.5–521.3)(77.5–537.5)(94.3–564.0)(99.8–511.3)(120.0–627.0)
No. of patients on lipid-lowering drugs22 (37%)24 (40%)24 (40%)35 (55%)34 (53%)34 (53%)
In vitro oxidizability of LDL
Lag time (min)80.2 ± 10.880.2 ± 9.281.0 ± 10.683.2 ± 10.6*
Diene appearance rate (nmol/mg LDL protein per min)13.9 ± 2.214.0 ± 2.513.8 ± 1.913.3 ± 1.9
Diene production (nmol/mg LDL protein)616.8 ± 60.4614.5 ± 73.8606.1 ± 59.2587.6 ± 60.2