Table 2. Renal lesions in diabetic mouse models

Mouse StrainDefectDiabetes TypeHyperglycemia Onset in MalesHyperglycemia Onset in FemalesAlbuminuriaMETIDGBMTVL
ME, mesangial expansion; TID, tubulointerstitial disease; GBMT, glomerular basement membrane thickening; VL, vascular lesion.
Ins2AkitaInsulin2 gene13–4 wk (severe)3–4 wk (mild)+∼20 wk?
NOD/LtJInsulinitis1>16 wk in 40–60%12 wk in 85–100%+∼16–20 wk+
Streptozotocin treatmentBeta cell death1∼1 wk after treatment∼1 wk after treatment+Absent or minimal?
LeprdbMutation of leptin receptor26–8 wk6–8 wk++∼16 wk+
LeprobAbsence of leptin2Transient 8–14 wkTransient 8–14 wk
KK Cg–Ay/JPolygenic28 wk8 wk++∼16 wk+