Table 2. Renal lesions in diabetic mouse models
| Mouse Strain | Defect | Diabetes Type | Hyperglycemia Onset in Males | Hyperglycemia Onset in Females | Albuminuria | ME | TID | GBMT | VL |
|---|---|---|---|---|---|---|---|---|---|
| ME, mesangial expansion; TID, tubulointerstitial disease; GBMT, glomerular basement membrane thickening; VL, vascular lesion. | |||||||||
| Ins2Akita | Insulin2 gene | 1 | 3–4 wk (severe) | 3–4 wk (mild) | + | ∼20 wk | − | ? | − |
| NOD/LtJ | Insulinitis | 1 | >16 wk in 40–60% | 12 wk in 85–100% | + | ∼16–20 wk | − | + | − |
| Streptozotocin treatment | Beta cell death | 1 | ∼1 wk after treatment | ∼1 wk after treatment | + | Absent or minimal | − | ? | − |
| Leprdb | Mutation of leptin receptor | 2 | 6–8 wk | 6–8 wk | ++ | ∼16 wk | − | + | − |
| Leprob | Absence of leptin | 2 | Transient 8–14 wk | Transient 8–14 wk | − | − | − | − | − |
| KK Cg–Ay/J | Polygenic | 2 | 8 wk | 8 wk | ++ | ∼16 wk | − | + | − |