Table 3. Multivariate analysis of combinations of inflammatory markers with change in serum creatinine per yeara

Modelβ (95% CI)P Value
a Adjusted baseline creatinine, HDL, AAI, major ECG abnormalities, age, race, weight, diabetes (none, impaired fasting glucose, diabetes), systolic BP, and pack-years smoking.
CRP and albumina
    logCRP (1 log mg/L)0.003 (0.001 to 0.005)0.010
    albumin (1 g/dl)−0.025 (−0.032 to −0.017)<0.001
CRP and factor VIIa
    logCRP0.003 (0.0004 to 0.005)0.023
    factor VII (10%)0.002 (0.001 to 0.002)<0.001
CRP and hemoglobina
    logCRP0.003 (0.0003 to 0.005)0.023
    hemoglobin (1 g/dl)−0.006 (−0.007 to −0.004)<0.001
CRP and WBC counta
    logCRP0.003 (0.001 to 0.005)0.004
    WBC count (1000/mm3)0.001 (−0.00005 to 0.0021)0.063
CRP, albumin, and hemoglobina
    logCRP0.002 (−0.0001 to 0.004)0.07
    albumin−0.020 (−0.027 to −0.012)<0.001
    hemoglobin−0.005 (−0.006 to −0.003)<0.001
CRP, albumin, and factor VIIa
    logCRP0.002 (−0.0006 to 0.004)0.14
    albumin−0.025 (−0.033 to −0.018)<0.001
    factor VII0.002 (0.001 to 0.003)<0.001
CRP, hemoglobin, and factor VIIa
    logCRP0.002 (−0.0005 to 0.004)0.12
    hemoglobin−0.005 (−0.007 to −0.004)<0.001
    factor VII0.001 (0.001 to 0.002)<0.001
CRP, albumin, hemoglobin, and factor VIIa
    logCRP0.001 (−0.001 to 0.003)0.30
    albumin−0.021 (−0.028 to −0.013)<0.001
    hemoglobin−0.004 (−0.006 to −0.002)<0.001
    factor VII0.001 (0.0007 to 0.002)<0.001