Table 2. Baseline characteristics of 1513 patients with type 2 diabetes and overt nephropathy according to tertile of baseline serum creatinine concentration and randomization to losartan or placebo treatment
| Lowest Tertile (Range, 0.9–1.6 mg/dl; Mean ± SD, 1.4 ± 0.1 mg/dl) | Middle Tertile (Range, 1.6–2.0 mg/dl; Mean ± SD, 1.8 ± 0.1 mg/dl) | Highest Tertile (Range, 2.1–3.6 mg/dl; Mean ± SD, 2.4 ± 0.3 mg/dl) | ||||
|---|---|---|---|---|---|---|
| Losartan | Placebo | Losartan | Placebo | Losartan | Placebo | |
| Patients (n) | 239 | 255 | 264 | 244 | 248 | 263 |
| Asian/black/white/hispanic/other (%) | 12/19/52/16/1 | 12/17/48/22/1 | 17/15/46/20/2 | 21/13/51/14/1 | 18/16/45/20/1 | 20/11/49/17/2 |
| Clinical parameters | ||||||
| Age (yr) | 59.6 ± 7.4 | 60.2 ± 7.5 | 60.7 ± 7.2 | 60.3 ± 7.6 | 59.6 ± 7.4 | 60.5 ± 7.4 |
| male gender (%) | 53 | 58 | 65 | 73 | 67 | 64 |
| body mass index (kg/m2) | 30.9 ± 6.6 | 29.8 ± 6.2 | 30.0 ± 5.9 | 29.3 ± 5.9 | 29.0 ± 6.4 | 29.2 ± 6.4 |
| systolic BP (mmHg) | 149 ± 18 | 149 ± 19 | 152 ± 19 | 153 ± 20 | 154 ± 19 | 157 ± 20 |
| diastolic BP (mmHg) | 82 ± 10 | 83 ± 10 | 83 ± 10 | 82 ± 11 | 82 ± 11 | 83 ± 10 |
| mean BP (mmHg) | 104 ± 11 | 105 ± 11 | 106 ± 11 | 106 ± 13 | 106 ± 11 | 108 ± 11 |
| oral antidiabetic drugs/insulin (%/%) | 55/62 | 55/58 | 48/59 | 53/55 | 42/64 | 42/64 |
| smoking (%) | 20 | 20 | 20 | 15 | 18 | 15 |
| Laboratory parameters | ||||||
| HbA1C (%) | 8.7 ± 1.7 | 8.7 ± 1.7 | 8.6 ± 1.6 | 8.4 ± 1.6 | 8.3 ± 1.6 | 8.2 ± 1.4 |
| total cholesterol (mg/dl) | 228 ± 54 | 227 ± 54 | 227 ± 57 | 229 ± 52 | 227 ± 55 | 230 ± 60 |
| HDL cholesterol (mg/dl) | 47 ± 17 | 47 ± 14 | 45 ± 15 | 44 ± 15 | 43 ± 14 | 44 ± 14 |
| triglycerides (mg/dl) | 239 ± 195 | 222 ± 208 | 207 ± 174 | 241 ± 235 | 194 ± 168 | 213 ± 150 |
| potassium (mEq/L) | 4.5 ± 0.5 | 4.6 ± 0.5 | 4.6 ± 0.4 | 4.6 ± 0.5 | 4.7 ± 0.5 | 4.7 ± 0.5 |
| uric acid (mg/dl) | 6.2 ± 1.6 | 6.1 ± 1.5 | 6.8 ± 1.7 | 6.9 ± 1.6 | 7.0 ± 1.7 | 7.1 ± 1.7 |
| creatinine clearance (ml/min per 1.73 m2) | ||||||
| mean ± SD | 50.7 ± 6.0 | 50.8 ± 5.7 | 39.1 ± 2.7 | 39.1 ± 2.8 | 28.9 ± 3.4 | 28.8 ± 3.3 |
| range | 43.1–76.7 | 44.5–76.7 | 34.5–43.1 | 34.5–43.1 | 19.2–33.7 | 21.6–33.7 |
| median albumin/creatinine ratio (g/mg) | 947 | 882 | 1045 | 1178 | 1737 | 1800 |