Table 4. Adverse events leading to patient withdrawal in 1513 patients with type 2 diabetes and overt nephropathy according to tertile of baseline serum creatinine and randomization to losartan or placebo treatmenta

EventLowest TertileMiddle TertileHighest Tertile
LosartanPlaceboLosartanPlaceboLosartanPlacebo
a ARF, acute renal failure.
b Cardiac arrest.
c Brain death.
d P < 0.01 versus Losartan.
Death002b01c0
Cardiovascular events101312121012
    myocardial infarction541567
    stroke357511
    angina/coronary disease244234
Heart failure/left ventricular dysfunction9111020623d
Increasing serum creatinine/ARF123596
Chronic renal insufficiency/failure41381110
ESRD1024813
Hyperkalemia215332
Angioedema000110
Hypertension/uncontrolled BP303311
Uncontrolled diabetes020100
Cancer132010
Other61314141920