Table 2. Diagnosis of epoetin-induced PRCA

Major features
    treatment with epoetin for at least several wk
    weekly drop of hemoglobin of ∼1 g/dl without transfusions or transfusion need of ∼1 U per wk to keep hemoglobin levels in an acceptable range
    reticulocytes < 10,000/mm3
    no major drop of leukocyte and platelet counts
Minor features
    skin or systemic allergic reactions
Confirmational investigations
    bone marrow aspirate
        normal cellularity and <5% erythroblasts
        evidence for block of maturation
        presence of anti-erythropoietin antibodies