Table 1. Specificity of p38 inhibition by NPC 31169 in vitro

KinaseIC50 (μM)a
a Concentrations of NPC 31169 (μM) resulting in a 50% reduction in the activity of kinase enzymes (IC50) as determined by in vitro phosphorylation of their substrates.
p38α0.0032
p38β0.12
p38γ>50
ERK2>50
JNK1>50
TGFβ-R1>50
TGFβ-R2>50
PKC>50
PKA>50
cdc2>50
EGFR>50
PKD>50
MAPKAPK2>50