Table 2. Factors associated with elevated plasma S-nitrosothiol levelsa

Low Titer (n = 190)High Titer (n = 60)Unadjusted Odds Ratio (95% CI)P ValueAdjusted Odds Ratio (95% CI)P Value
a Data are summarized as means ± SD or percentages. The low-titer and high-titer groups were defined on the basis of the fourth quartile of S-nitrosothiol values. Urea Kt/V was calculated according to the second Daugirdas formula. CRP, C-reactive protein; CI, confidence interval.
b t test, P < 0.001.
Age (yr)59.8 ± 15.362.6 ± 13.61.01 (0.99 to 1.03)0.21
Time on dialysis (yr)7.4 ± 7.27.9 ± 7.21.01 (0.97 to 1.05)0.67
Urea Kt/V1.46 ± 0.381.46 ± 0.320.68 (0.30 to 1.56)0.36
S-Nitrosothiol level (μM)1.64 ± 0.242.19 ± 0.14b
Systolic BP (mmHg)141 ± 26.1151 ± 20.61.02 (1.00 to 1.03)0.01
Diastolic BP (mmHg)76 ± 16.879 ± 14.61.01 (0.99 to 1.03)0.18
Pulse pressure (mmHg)64.8 ± 15.871.2 ± 16.01.03 (1.01 to 1.05)0.0071.03 (1.01 to 1.05)0.007
Hemoglobin (g/dl)11.1 ± 1.211.1 ± 1.00.96 (0.74 to 1.24)0.73
Log ultra-sensitive CRP (mg/L)1.56 ± 1.241.57 ± 1.211.01 (0.79 to 1.29)0.95
Diabetes mellitus (%)20.516.70.77 (0.36 to 1.66)0.51
Hypercholesterolemia (%)40.035.00.81 (0.44 to 1.48)0.49
Active smokers (%)12.615.01.22 (0.53 to 2.80)0.64
Indexed ventricular mass (g/m2)112 ± 37123 ± 351.01 (1.00 to 1.02)0.06
Left ventricular hypertrophy (%)33.542.91.49 (0.81 to 2.74)0.20
Prior ischemic cardiac disease (%)23.718.30.72 (0.35 to 1.51)0.39
Death (%)12.121.72.01 (0.95 to 4.30)0.07
Cardiac death (%)4.213.33.50 (1.25 to 9.78)0.016
Major adverse cardiac events (%)10.023.32.74 (1.28 to 5.88)0.01