Period | SRL-CsA-ST | SRL-ST | Difference |
---|---|---|---|

^{a} ITT, intention-to-treat. | |||

^{b} Number of patients used to calculate the mean. | |||

^{c} Random coefficients regression model. | |||

^{d} Including values after discontinuation. | |||

On-therapy, 6 to 36 mo | |||

slope (mean ± SEM) | −3.631 ± 0.444 (204)^{b} | 1.725 ± 0.455 (194) | −5.356 ± 0.636 |

95% CI | −4.505, −2.757 | 0.829, 2.622 | −6.608, −4.104 |

P value^{c} | <0.001 | <0.001 | <0.001 |

ITT analysis, 6 to 36 mo^{d} | |||

slope (mean ± SEM) | −3.037 ± 0.453 (213) | 0.827 ± 0.449 (212) | −3.864 ± 0.638 |

95% CI | −3.929, −2.146 | −0.056, 1.709 | −5.118, −2.610 |

P value | <0.001 | 0.066 | <0.001 |