Table 4. Slope of calculated GFR versus time (ml/min per year)a

PeriodSRL-CsA-STSRL-STDifference
a ITT, intention-to-treat.
b Number of patients used to calculate the mean.
c Random coefficients regression model.
d Including values after discontinuation.
On-therapy, 6 to 36 mo
    slope (mean ± SEM)−3.631 ± 0.444 (204)b1.725 ± 0.455 (194)−5.356 ± 0.636
    95% CI−4.505, −2.7570.829, 2.622−6.608, −4.104
    P valuec<0.001<0.001<0.001
ITT analysis, 6 to 36 mod
    slope (mean ± SEM)−3.037 ± 0.453 (213)0.827 ± 0.449 (212)−3.864 ± 0.638
    95% CI−3.929, −2.146−0.056, 1.709−5.118, −2.610
    P value<0.0010.066<0.001