Table 2. Association of estimated creatinine clearance with development of a lower extremity PAD eventa

Creatinine clearance in ml/min per 1.73 m2
≥60(n = 1275)30–59 (n = 1438)<30(n = 44)
a Multivariable analysis is adjusted for age, race, conventional cardiovascular risk factors (diabetes (categorized as treated and untreated) hypertension, fasting LDL, HDL, triglycerides, lipoprotein(a), current smoking, body mass index, alcohol use and exercise) and also aspirin use, HMG-CoA reductase inhibitor use, treatment arm, education, and baseline severity of coronary artery disease (number of prior MI and prior coronary artery bypass graft or PTCA.
b P ≤ 0.001.
c P ≤ 0.01.
d P ≤ 0.05.
Total number of events44785
Event rate per 100 person years (95% confidence interval)0.55 (0.40 to 0.73)0.92 (0.73 to 1.15)2.73 (0.69 to 6.38)
Univariate HR (CI)1.00 (referent)1.67 (1.16 to 2.42)4.95 (1.96 to 12.52)b
Multivariate HR (CI)1.00 (referent)1.63 (1.04 to 2.54)d3.24 (1.20 to 8.78)d