Table 1. Baseline characteristics by original study and CKD groupa

Baseline VariablesARIC (n = 12,904)CHS (n = 4,232)FHS (n = 1,950)Offspring (n = 3,548)CKDb (n = 1,664)No CKDb (n = 20,970)Total (n = 22,634)
a CKD, chronic kidney disease; ARIC, Atherosclerosis Risk in Communities Study; CHS, Cardiovascular Health Study; FHS, Framingham Heart Study; Offspring, Framingham Offspring Study; BMI, body mass index; LVH, left ventricular hypertrophy.
b The P value for all variables between subjects with CKD and those without CKD is <0.05 with the exception of LVH and HDL cholesterol.
All values for continuous variables are means ± SD.
Demographic data (%)
    age (yr)53.9 ± 5.772.9 ± 5.468.1 ± 7.243.9 ± 10.068.1 ± 11.456.2 ± 11.257.1 ± 11.6
    male44.538.837.648.333.144.243.4
    black27.514.5009.619.118.4
    high school graduate77.972.465.592.770.178.878.2
Lifestyle (%)
    smoking, current25.612.425.836.215.725.524.8
    alcohol, current57.451.461.676.752.360.259.7
Medical history (%)
    diabetes9.513.710.93.813.99.29.5
    hypertension36.159.952.421.962.138.039.7
Medication use (%)
    antihypertensive agents26.638.827.98.945.924.726.2
    lipid-lowering agents2.44.32.00.63.42.32.4
    diabetes agents4.56.74.31.07.14.14.3
Physical characteristics
    BMI (kg/m2)27.5 ± 5.226.5 ± 4.126.2 ± 4.127.7 ± 4.626.9 ± 4.527.3 ± 4.927.2 ± 4.9
    systolic BP (mmHg)121.1 ± 18.6136.3 ± 21.4135.6 ± 18.6122.0 ± 16.3134.7 ± 22.1124.6 ± 19.6125.3 ± 20.0
    diastolic BP (mmHg)73.9 ± 11.271.3 ± 11.575.9 ± 9.878.0 ± 9.773.6 ± 11.574.3 ± 11.174.3 ± 11.1
    LVH (%)4.83.41.20.33.43.53.5
Laboratory values
    creatinine calibrated (mg/dl)0.9 ± 0.20.9 ± 0.30.9 ± 0.30.8 ± 0.21.3 ± 0.30.8 ± 0.20.9 ± 0.2
    GFR (ml/min per 1.73 m2)93.3 ± 19.879.9 ± 22.083.2 ± 28.398.7 ± 28.351.7 ± 7.693.9 ± 21.490.8 ± 23.4
    total cholesterol (mg/dl)214 ± 42212 ± 39230 ± 41233 ± 47224 ± 46218 ± 43218 ± 43
    HDL cholesterol (mg/dl)52 ± 1756 ± 1651 ± 1549 ± 1352 ± 1652 ± 1652 ± 16