Table 3. Results of weighted multivariable model for the probability of mortality as a function of iron administered during the prior 6 mo

VariableCategoryAdjusteda
Hazard Ratio (95% CI)P value
a Adjusted for other variables in the table.
b Cumulative iron dose during rolling 6 mo windows.
c At end of enrollment period.
d During enrollment period.
e During the month prior to each rolling 6-mo iron dosing window.
f At the beginning of the 6-mo iron dosing window; in the final model, a separate coefficient was included for each duration (in mo) of time since ESRD.
Iron (mg)bNoneRef.0.78
> 0 to 7001.04 (0.91–1.19)
> 700 to 10001.00 (0.87–1.14)
> 1000 to 18000.96 (0.84–1.09)
> 18001.04 (0.90–1.21)
GenderMaleRef0.07
Female0.90 (0.81–1.01)
RaceWhiteRef< 0.0001
Black0.74 (0.66–0.83)
Native American1.01 (0.70–1.46)
Asian/Pacific Islander0.91 (0.69–1.21)
Other0.86 (0.70–1.05)
Age (yr)c18 to < 30Ref< 0.000100
30 to < 402.53 (1.33–4.81)
40 to < 502.47 (1.37–4.43)
50 to < 603.26 (1.82–5.83)
60 to < 705.04 (2.83–9.00)
70 to < 806.45 (3.62–11.48)
≥ 807.89 (4.38–14.22)
Duration of ESRD (yr)f0.5 to < 2Ref.< 0.0001
2 to < 31.03 (0.74–1.43)
3 to < 41.21 (0.88–1.69)
4 to < 61.30 (0.93–1.80)
6 to < 81.41 (1.01–1.99)
≥ 81.65 (1.17–2.31)
Diabetic statuscNon-diabeticRef.< 0.0001
Adult-onset1.29 (1.03–1.61)
Juvenile-onset0.82 (0.74–0.91)
Hospitalizationsd0Ref.< 0.0001
≥ 11.56 (1.41–1.73)
IV antibiotic doses administeredd0Ref.0.01
11.16 (0.97–1.39)
≥ 21.20 (1.06–1.37)
URR (%)e< 53.41.26 (0.97–1.64)0.22
53.4 to < 58.71.13 (0.90–1.41)
58.7 to < 62.41.14 (0.90–1.44)
62.4 to < 671.13 (0.98–1.31)
≥ 67Ref.
Epoetin dose (units/mo)e0Ref.0.22
        > 0 to 20,0000.94 (0.69–1.28)
> 20,000 to 40,0001.03 (0.76–1.38)
> 40,0001.10 (0.83–1.47)
Albumin (g/dl)e≤ 34.96 (3.55–6.92)< 0.0001
3.0 to < 3.52.97 (2.25–3.92)
3.5 to < 42.02 (1.57–2.61)
4 to < 4.51.32 (1.03–1.68)
≥ 4.5Ref.
AST/SGOT (U/L)e< 50Ref.< 0.0001
≥ 501.63 (1.29–2.07)
Bicarbonate (mEq/L)e6 to < 181.28 (1.08–1.52)0.01
18 to < 211.03 (0.89–1.18)
21 to < 241.07 (0.93–1.24)
24 to < 35Ref.
Calcium (mg/dl)e5 to < 80.95 (0.77–1.17)0.87
8 to < 91.02 (0.90–1.15)
9 to < 10Ref.
10 to < 111.02 (0.89–1.17)
11 to < 150.90 (0.70–1.17)
Ferritin (ng/ml)e< 1000.96 (0.82–1.12)0.0005
100 to < 800Ref.
≥ 8001.29 (1.13–1.47)
Hemoglobin (g/dl)e< 71.68 (1.09–2.58)0.09
7 to < 81.25 (0.95–1.64)
8 to < 91.20 (0.99–1.46)
9 to < 101.23 (1.05–1.44)
10 to < 111.12 (0.97–1.30)
11 to < 12Ref.
12 to < 161.05 (0.85–1.30)
Phosphate (mg/dl)e< 5Ref.0.62
5 to < 71.04 (0.92–1.17)
≥ 71.08 (0.93–1.25)
TSAT (%)e< 201.26 (1.13–1.41)< 0.0001
≥ 20Ref.