Table 3. Correlation analysis of ERK activation with clinical and pathological disease parametersa

Serum Creatinine (μmol/L)Creatinine Clearance (ml/min)Proteinuria (g/d)Glomerular Cellularity (cells/gcs)Glomerular Seg Lesion (%)Interst Damage (0–3+)
a All patients with glomerulopathies were analysed as a single cohort. Analysis of serum creatinine, creatinine clearance, proteinuria, and glomerular cellularity used the Pearson correlation coefficient. Analysis of the percentage of glomeruli with segmental lesions (proliferative and/or necrotic), and the score of interstitial damage (fibrosis and tubular atrophy) used the Spearman correlation coefficient. Data are shown as the correlation coefficient r and statistical values given in parenthesis. NS, not significant.
p-ERK+ cells/gcs0.33−0.32−0.200.350.37
(P = 0.0497)NSNS(P = 0.042)(P = 0.04)
p-ERK+ tubular cells/mm20.34−0.46−0.030.5
(P = 0.04)(P = 0.0038)NS(P = 0.0036)