Table 1. Effect of mesenchymal and hematopoietic stem cells on renal histologya

TreatmentTime (days)CastsTubular Cell DegenerationbCell Loss
a Histology data are mean scores ± SE. MSC, mesenchymal stem cells; HSC, hematopoietic stem cells.
b Tubular cell degeneration consisted of brush border loss, nuclear changes, vacuolization, periodic acid-Schiff–positive droplets, and cell debris in tubular lumens.
c P < 0.05,
d P < 0.01 versus cisplatin + saline at the corresponding time.
e P < 0.05,
f P < 0.01 versus cisplatin + saline at 1, 11, and 29 d.
g P < 0.05,
h P < 0.01 versus HSC at the corresponding time. At 1 d after cisplatin injection, tubular changes were not observed (casts: 0; tubular cell degeneration: 0; cell loss: 0).
Cisplatin + saline41.77 ± 0.20f1.54 ± 0.14f1.38 ± 0.18f
71.60 ± 0.30e1.40 ± 0.22e0.60 ± 0.16
110.33 ± 0.1600
290.43 ± 0.2000
Cisplatin + MSC40.50 ± 0.19dg0.62 ± 0.18ch0.12 ± 0.12dh
70.60 ± 0.240.40 ± 0.24c0
110.25 ± 0.2500
290.17 ± 0.170.17 ± 0.170
Cisplatin + HSC41.67 ± 0.321.67 ± 0.211.33 ± 0.21
110.33 ± 0.3300
29000