Table 3. Multivariate odds ratios for coronary events according to estimated CrCl and the impact of adjustment for individual inflammatory markersa

BiomarkerEstimated CrCl (ml/min)
≥90 (Cases = 117, Controls = 232)75–89 (Cases = 65, Controls = 157)60–74 (Cases = 43, Controls = 82)<60 (Cases = 19, Controls = 15)
a To convert mg/L to mg/dl, divide by 10.
b Adjusted for age, race, BMI, lean body mass, physical activity level, hemoglobin A1C level, total cholesterol level, HDL level, diabetes, hypertension, smoking status, and family history of MI.
Base modelb1.00 (referent)0.95 (0.62–1.46)1.07 (0.63–1.83)2.33 (1.01–5.38)
+hs-CRP (mg/l)1.00 (referent)0.98 (0.63–1.51)1.17 (0.68–2.02)2.17 (0.92–5.12)
+E-selectin (ng/ml)1.00 (referent)0.95 (0.61–1.46)1.07 (0.63–1.83)2.37 (1.02–5.48)
+Fibrinogen (mg/dl)1.00 (referent)0.95 (0.62–1.46)1.08 (0.63–1.85)2.34 (1.01–5.41)
+Homocysteine (μmol/L)1.00 (referent)0.98 (0.63–1.51)1.16 (0.67–2.01)2.52 (1.08–5.89)
+IL-6 (pg/ml)1.00 (referent)0.90 (0.57–1.40)0.94 (0.54–1.65)2.43 (1.02–5.81)
+ICAM-1 (ng/ml)1.00 (referent)0.95 (0.67–1.46)1.07 (0.63–1.83)2.31 (1.00–5.35)
+Pyridoxal 5′-phosphate (ng/ml)1.00 (referent)0.95 (0.61–1.47)1.03 (0.60–1.77)2.25 (0.97–5.21)
+sTNFR I (pg/ml)1.00 (referent)0.92 (0.59–1.43)0.98 (0.56–1.72)1.73 (0.67–4.45)
+sTNFR II (pg/ml)1.00 (referent)0.93 (0.60–1.44)1.02 (0.58–1.77)1.82 (0.71–4.67)
+VCAM-1 (ng/ml)1.00 (referent)0.96 (0.62–1.48)1.10 (0.64–1.88)2.39 (1.02–5.61)