Table 4. Multivariatea odds ratios for coronary events for hs-CRP, IL-6, pyridoxal 5′-phosphate, and sTNFR I and II levels as continuous variables stratified by estimated CrCl Level

BiomarkerEstimated CrCl (ml/min)P Value for Interaction
≥90 (Cases = 117, Controls = 232)75–89 (Cases = 65, Controls = 157)<75 (Cases = 62, Controls = 97)
a Adjusted for age, race, BMI, lean body mass, physical activity level, hemoglobin A1C level, total cholesterol level, HDL level, diabetes, hypertension, smoking status, and family history of MI. Note, the lowest cut-point of estimated CrCl is <74 ml/min, because there were too few participants in the <60 ml/min category to analyze this subgroup separately. To convert mg/L to mg/dl, divide by 10.
hs-CRP (per 5 mg/L)0.99 (0.76–1.29)1.23 (0.86–1.76)1.68 (1.13–2.52)0.004
IL-6 (per 10 pg/ml)0.34 (0.07–1.53)1.01 (0.38–2.71)3.89 (1.18–12.85)0.02
Pyridoxal 5′-phosphate (per 100 ng/ml)0.96 (0.70–1.33)0.92 (0.67–1.24)0.54 (0.29–0.98)0.05
sTNFR I (per 1000 pg/ml)1.05 (0.43–2.57)0.81 (0.28–2.32)2.86 (1.25–6.55)0.08
sTNFR II (per 1000 pg/ml)0.85 (0.55–1.32)1.09 (0.62–1.93)1.64 (1.08–2.49)0.06