Table 1. Characteristics of study population at baseline, by serum creatinine level
| Non-Elevated Creatinine (n = 3019) | Elevated Creatininea (n = 330) | P | |
|---|---|---|---|
| a Serum creatinine ≥1.3 mg/dl for females and ≥1.5 mg/dl for males. | |||
| b Homozygous or heterozygous for apoE-4 allele. | |||
| c All participants from the Pittsburgh site received detailed evaluations for dementia regardless of their risk category. | |||
| N (%) or mean (SD) | |||
| Age (yr) | 74.6 (4.8) | 76.9 (5.4) | <.001 |
| Gender | |||
| male | 1185 (39%) | 191 (58%) | <.001 |
| female | 1834 (61%) | 139 (42%) | |
| Race | |||
| white | 2596 (86%) | 261 (79%) | .001 |
| non-white | 423 (14%) | 69 (21%) | |
| Education (yr) | 12.7 (2.9) | 12.5 (3.1) | .2 |
| Body mass index (kg/m2) | 26.6 (4.5) | 27.0 (4.4) | .1 |
| Coronary heart disease | 561 (19%) | 103 (31%) | <.001 |
| Diabetes | 406 (13.5%) | 52 (15.8%) | .2 |
| Hypertension | 1665 (55%) | 249 (75%) | <.001 |
| ApoE-4 alleleb | 678 (22.5%) | 58 (17.6%) | .03 |
| Smoker | |||
| never | 1367 (45%) | 126 (38%) | .008 |
| former | 1368 (45%) | 179 (54%) | |
| current | 284 (9%) | 25 (8%) | |
| Self-reported health | |||
| fair–poor | 459 (15.2%) | 80 (24.2%) | <.001 |
| good–excellent | 2557 (84.8%) | 250 (76%) | |
| Clinic site | |||
| Pittsburghc | 775 (25.7%) | 98 (29.7%) | .11 |
| other sites | 2244 (74.3%) | 232 (70.3%) | |