Table 1. Characteristics of study population at baseline, by serum creatinine level

Non-Elevated Creatinine (n = 3019)Elevated Creatininea (n = 330)P
a Serum creatinine ≥1.3 mg/dl for females and ≥1.5 mg/dl for males.
b Homozygous or heterozygous for apoE-4 allele.
c All participants from the Pittsburgh site received detailed evaluations for dementia regardless of their risk category.
N (%) or mean (SD)
Age (yr)74.6 (4.8)76.9 (5.4)<.001
Gender
    male1185 (39%)191 (58%)<.001
    female1834 (61%)139 (42%)
Race
    white2596 (86%)261 (79%).001
    non-white423 (14%)69 (21%)
Education (yr)12.7 (2.9)12.5 (3.1).2
Body mass index (kg/m2)26.6 (4.5)27.0 (4.4).1
Coronary heart disease561 (19%)103 (31%)<.001
Diabetes406 (13.5%)52 (15.8%).2
Hypertension1665 (55%)249 (75%)<.001
ApoE-4 alleleb678 (22.5%)58 (17.6%).03
Smoker
    never1367 (45%)126 (38%).008
    former1368 (45%)179 (54%)
    current284 (9%)25 (8%)
Self-reported health
    fair–poor459 (15.2%)80 (24.2%)<.001
    good–excellent2557 (84.8%)250 (76%)
Clinic site
    Pittsburghc775 (25.7%)98 (29.7%).11
    other sites2244 (74.3%)232 (70.3%)