Table 3. Association between renal function and incident dementia: Adjustedc Hazard Ratio (95% CI)

Measurement of Renal FunctionAll Subtype Dementia (477 cases)Vascular-Type Dementiaa (211 cases)Pure Alzheimer-Type Dementiab (244 cases)
a Possible or probable vascular-type dementia (29), alone or with superimposed Alzheimer-type dementia. Subjects who developed pure Alzheimer-type dementia or minimal cognitive impairment were excluded from this analysis.
b Possible or probable Alzheimer-type dementia (28) without superimposed vascular-type dementia. Subjects who developed vascular-type dementia or minimal cognitive impairment were excluded from this analysis.
c Adjusted for age, gender, race, body weight (quadratic term), educational achievement, prevalent coronary heart disease, diabetes, hypertension, smoking status, and apoE genotype.
d Creatinine ≥1.3 mg/dl if female or ≥1.5 mg/dl if male.
1/SCr (0.5-unit decrement)
    total cohort1.26 (1.02 to 1.54)1.29 (0.93 to 1.79)1.22 (0.89 to 1.69)
        good–excellent self-reported health1.41 (1.12 to 1.79)1.64 (1.11 to 2.42)1.26 (0.90 to 1.78)
        fair or poor self-reported health0.79 (0.50 to 1.23)0.63 (0.34 to 1.19)0.99 (0.52 to 1.88)
Elevated serum creatinined
    total cohort1.37 (1.06 to 1.78)1.58 (1.10 to 2.26)1.09 (0.72 to 1.65)
        good–excellent self-reported health1.62 (1.21 to 2.18)1.94 (1.28 to 2.93)1.28 (0.81 to 2.03)
        fair or poor self-reported health0.75 (0.43 to 1.31)0.80 (0.38 to 1.69)0.61 (0.23 to 1.59)