Table 2. Renal expression of receptors for AGE

ParametersControl C57BL/6 (n = 7–8)Diabetic C57BL/6 (n = 7–8)Control apo E-KO (n = 7–8)Diabetic apo E-KO (n = 7–8)Diabetic apo E-KO + Aminoguanidine (n = 7–8)Diabetic apo E-KO + ALT-711 (n = 6–7)
a Data are mean ± SEM. AGE, advanced glycation end product; RAGE, receptor for advanced glycation end product.
b P < 0.05, c P < 0.01 versus appropriate nondiabetic control group.
d P < 0.05, e P < 0.01 versus appropriate C57BL/6 group.
f P < 0.05, g P < 0.01 versus diabetic apo E-KO mice.
AGE R-2 mRNA1.30 ± 0.211.41 ± 0.391 ± 0.090.87 ± 0.08d0.46 ± 0.05f0.34 ± 0.04g
AGE R-3 mRNA0.81 ± 0.442.24 ± 1.05b1 ± 0.362.22 ± 0.31c3.59 ± 1.342.47 ± 1.22
RAGE mRNA1.02 ± 0.231.93 ± 0.73b1 ± 0.191.46 ± 0.141.02 ± 0.07f0.72 ± 0.11g
RAGE-positive staining (%)0.42 ± 0.132.08 ± 0.47c1.88 ± 0.37c2.07 ± 0.470.62 ± 0.17g0.93 ± 0.24g