Table 4. Digoxin dose and serum digoxin levels at one month, by renal function

Mean Prescribed Digoxin Dose (mg)Serum Digoxin Level at One Month (ng/ml)
Total NMean (SD)P Value for TrendTotal NMean (SD)P Value for Trend
a GFR expressed in ml/min per 1.73 m2.
Estimated GFR Level*
    >6018270.26 (0.07)<0.00019930.83 (0.46)<0.0001
    30 to 6014680.22 (0.06)7921.01 (0.58)
    <301020.17 (0.06)551.35 (0.64)
Creatinine level
    ≤1.0 mg/dl8780.27 (0.08)<0.00014790.84 (0.49)<0.0001
    1.1 to 1.5 mg/dl19200.24 (0.07)10450.90 (0.52)
    1.6 to 2.0 mg/dl4620.21 (0.06)2371.07 (0.57)
    >2.0 mg/dl1370.19 (0.06)791.28 (0.68)