Table 1. IC50 values for inhibition of albumin uptake and cholesterol biosynthesis by various statinsa

StatinProtein Uptake IC50 (μM)Cholesterol Synthesis IC50 (μM)
a Values were determined from dose-response curves for each statin and are the combined results of two to eight independent experiments, expressed as mean IC50 value with 95% confidence intervals shown in brackets.
Fluvastatin0.11 (0.10 to 0.12)0.04 (0.03 to 0.04)
Simvastatin0.29 (0.20 to 0.43)0.01 (0.01 to 0.02)
Atorvastatin0.94 (0.49 to 1.79)0.07 (0.04 to 0.15)
Rosuvastatin1.69 (1.08 to 2.63)0.13 (0.05 to 0.35)
Pravastatin26.46 (4.46 to 156.86)0.55 (0.12 to 2.62)