Table 3.

Systemic and renal hemodynamic parameters (substudy, n = 20)a

Candesartan, 32 mgn = 7Candesartan, 64 mgn = 13P
ABP systolic (mmHg)
    first 16 mg candesartan137 ± 12129 ± 12NS
    high-dose candesartan134 ± 7131 ± 14NS
ABP diastolic (mmHg)
    first 16 mg candesartan82 ± 1277 ± 8NS
    high-dose candesartan81 ± 879 ± 8NS
GFR (ml/min)
    first 16 mg candesartan105 ± 42103 ± 30NS
    high-dose candesartan103 ± 27101 ± 28NS
Renal plasma flow (ml/min)
    first 16 mg candesartan679 ± 466561 ± 212NS
    high-dose candesartan503 ± 166473 ± 122NS
Filtration fraction (%)
    first 16 mg candesartan20 ± 920 ± 5NS
    high-dose candesartan21 ± 522 ± 6NS
  • a All data are expressed as mean ± SD. P values in the table are given for comparison between treatment groups (t test). There were no significant differences between the treatment groups and no significant changes attributable to treatment within the groups. ABP, ambulatory 24-h blood pressure.